Male hypogonadotropic hypogonadism (HH) is due to genetic or acquired factors from the hypothalamus, synthesis, transport, and pituitary secretion gonadotropic-releasing hormone (GnRH), or from gonadotropin disorders.
Gonadorelin is responsible for the release of follicle stimulating hormone and luteinizing hormone from the anterior pituitary. In the pituitary, GnRH stimulates synthesis and release of FSH and LH. This process is controlled by the frequency and amplitude of GnRH pulses and the feedback of androgens and estrogens.