Male hypogonadotropic hypogonadism (HH) is due to genetic or acquired factors from the hypothalamus, synthesis, transport, and pituitary secretion gonadotropic-releasing hormone (GnRH), or from gonadotropin disorders.  

Gonadorelin is responsible for the release of follicle stimulating hormone and luteinizing hormone from the anterior pituitary.  In the pituitary, GnRH stimulates synthesis and release of FSH and LH.  This process is controlled by the frequency and amplitude of GnRH pulses and the feedback of androgens and estrogens.  


  • Significantly increases stimulation of LH and FSH
  • Efficiently promotes testicular volume (TV)
  • Increased sperm production
  • Raises total testosterone serum

GnRH Therapy is most effective in the induction of spermatogenesis and pregnancies in hypogonadotropic hypogonadal men, despite maldescended testes, low initial testicular volume or sperm concentrations below the normal limit.